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Fehon, Richard G.
One or more keywords matched the following properties of Fehon, Richard G.
PropertyValue
keywords Hippo pathway
overview The Fehon laboratory studies the organization and function of signaling pathway components at the cell cortex, particularly relating to the Hippo growth control pathway. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway. We study this question in Drosophila because of the utility of this system for studying the functions of individual genes, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.
One or more keywords matched the following items that are connected to Fehon, Richard G.
Item TypeName
Concept Sodium-Potassium-Exchanging ATPase
Concept Chromosomes, Human, Pair 22
Concept Homozygote
Concept Insect Hormones
Concept Myosin-Light-Chain Kinase
Concept Immunohistochemistry
Concept Heat-Shock Proteins
Concept Hamartoma
Concept Protein Kinases
Concept Sequence Homology, Nucleic Acid
Concept Histones
Concept Humans
Concept Sequence Homology, Amino Acid
Concept Sodium-Hydrogen Exchangers
Concept Mitogen-Activated Protein Kinases
Concept Microscopy
Concept In Situ Hybridization
Concept Mice, Knockout
Concept MAP Kinase Kinase Kinases
Concept src Homology Domains
Concept Histone Code
Concept Protein Kinase C
Concept Glycogen Synthase Kinase 3
Concept Two-Hybrid System Techniques
Concept Structural Homology, Protein
Concept JNK Mitogen-Activated Protein Kinases
Academic Article The involvement of the Notch locus in Drosophila oogenesis.
Academic Article Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.
Academic Article Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin.
Academic Article Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.
Academic Article Advances in neurofibromatosis 2 (NF2): a workshop report.
Academic Article A systematic screen for dominant second-site modifiers of Merlin/NF2 phenotypes reveals an interaction with blistered/DSRF and scribbler.
Academic Article Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.
Academic Article The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.
Academic Article The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.
Academic Article Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila.
Academic Article ERM proteins and merlin: integrators at the cell cortex.
Academic Article The Notch locus and the cell biology of neuroblast segregation.
Academic Article Protein interaction mapping: a Drosophila case study.
Academic Article Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function.
Academic Article Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.
Academic Article Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants.
Academic Article Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase.
Academic Article Understanding ERM proteins--the awesome power of genetics finally brought to bear.
Academic Article Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane.
Academic Article Notch and the molecular genetics of neuroblast segregation in Drosophila.
Academic Article Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large.
Academic Article Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway.
Academic Article Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development.
Academic Article Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity.
Academic Article Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling.
Academic Article Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.
Academic Article A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene.
Academic Article Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex.
Academic Article Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling.
Academic Article Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila.
Academic Article Organizing the cell cortex: the role of ERM proteins.
Academic Article In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila.
Academic Article The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC.
Academic Article The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs.
Academic Article The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.
Academic Article Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.
Academic Article Size does matter!
Academic Article Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner.
Academic Article Live Imaging of Hippo Pathway Components in Drosophila Imaginal Discs.
Academic Article The CAF-1 complex couples Hippo pathway target gene expression and DNA replication.
Academic Article Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
Academic Article Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.
Academic Article Cortical tension promotes Kibra degradation via Par-1.
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